Nef-Induced CD4 Downregulation: a Diacidic Sequence in Human Immunodeficiency Virus Type 1 Nef Does Not Function as a Protein Sorting Motif through Direct Binding to β-COP

The Nef protein from the human immunodeficiency virus (HIV) induces CD4 cell surface downregulation by interfering with the endocytic machinery. It has been recently proposed that binding of HIV type 1 Nef to the β subunit of COPI coatomers participated in the Nef-induced CD4 downregulation through...

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Bibliographic Details
Main Authors: Janvier, K., Craig, H., Le Gall, S., Benarous, R., Guatelli, J., Schwartz, O., Benichou, S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC114888/
https://ncbi.nlm.nih.gov/pubmed/11264386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.8.3971-3976.2001
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