A Diacidic Motif in Human Immunodeficiency Virus Type 1 Nef Is a Novel Determinant of Binding to AP-2

A key function of the Nef protein of immunodeficiency viruses is the downregulation of the T-cell and macrophage coreceptor, CD4, from the surfaces of infected cells. CD4 downregulation depends on a conserved (D/E)XXXL(L/I)-type dileucine motif in the C-terminal, flexible loop of Nef, which mediates...

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Bibliographic Details
Main Authors: Lindwasser, O. Wolf, Smith, William J., Chaudhuri, Rittik, Yang, Peter, Hurley, James H., Bonifacino, Juan S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224420/
https://ncbi.nlm.nih.gov/pubmed/18032517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01874-07
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