Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity

Chemical modification of proteins with polyethylene glycol (PEGylation) can increase plasma half-lives, stability, and therapeutic potency. To make a PEGylated recombinant immunotoxin with improved therapeutic properties, we prepared a mutant of anti-Tac(Fv)-PE38 (LMB-2), a recombinant immunotoxin c...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Tsutsumi, Yasuo, Onda, Masanori, Nagata, Satoshi, Lee, Byungkook, Kreitman, Robert J., Pastan, Ira
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2000
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26985/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10890891/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.140210597
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