Anti-AIDS Agents 72. Bioisosteres (7-carbon-DCKs) of the potent anti-HIV lead DCK

Three 9,10-di-O-(−)-camphanoyl–7,8,9,10-tetrahydro-benzo[h]chromen-2-one (7-carbon-DCK) analogs (3a–c) were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes. All three new carbon bioisosteres of the anti-HIV lead DCK showed anti-HIV activity. Compound 3a had an EC(50)...

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Hlavní autoři: Wang, Yang, Huang, Shao-Xu, Xia, Peng, Xia, Yi, Yang, Zheng-Yu, Kilgore, Nicole, Morris-Natschke, Susan L., Lee, Kuo-Hsiung
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697499/
https://ncbi.nlm.nih.gov/pubmed/17533128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.05.026
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