Pancreatic protease activation by alcohol metabolite depends on Ca(2+) release via acid store IP(3) receptors

Toxic alcohol effects on pancreatic acinar cells, causing the often fatal human disease acute pancreatitis, are principally mediated by fatty acid ethyl esters (non-oxidative products of alcohol and fatty acids), emptying internal stores of Ca(2+). This excessive Ca(2+) liberation induces Ca(2+)-dep...

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Main Authors: Gerasimenko, Julia V., Lur, György, Sherwood, Mark W., Ebisui, Etsuko, Tepikin, Alexei V., Mikoshiba, Katsuhiko, Gerasimenko, Oleg V., Petersen, Ole H.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696551/
https://ncbi.nlm.nih.gov/pubmed/19528657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904818106
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