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The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge

IL-12 plays a central role in both the induction and magnitude of a primary Th1 response. A critical question in designing vaccines for diseases requiring Th1 immunity such as Mycobacterium tuberculosis and Leishmania major is the requirements to sustain memory/effector Th1 cells in vivo. This repor...

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Bibliografski detalji
Glavni autori: Stobie, Laura, Gurunathan, Sanjay, Prussin, Calman, Sacks, David L., Glaichenhaus, Nicolas, Wu, Chang-You, Seder, Robert A.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC26964/
https://ncbi.nlm.nih.gov/pubmed/10890924
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