The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge

IL-12 plays a central role in both the induction and magnitude of a primary Th1 response. A critical question in designing vaccines for diseases requiring Th1 immunity such as Mycobacterium tuberculosis and Leishmania major is the requirements to sustain memory/effector Th1 cells in vivo. This repor...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Stobie, Laura, Gurunathan, Sanjay, Prussin, Calman, Sacks, David L., Glaichenhaus, Nicolas, Wu, Chang-You, Seder, Robert A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26964/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10890924/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160197797
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