An Architectural Role for a Nuclear Non-coding RNA: NEAT1 RNA is Essential for the Structure of Paraspeckles

NEAT1 RNA, a highly abundant 4 kb ncRNA, is retained in nuclei in ~10–20 large foci that we show is completely coincident with paraspeckles, nuclear domains implicated in mRNA nuclear retention. Depletion of NEAT1 RNA via RNAi eradicates paraspeckles, suggesting it controls sequestration of the para...

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Main Authors: Clemson, Christine M., Hutchinson, John N., Sara, Sergio A., Ensminger, Alexander W., Fox, Archa H., Chess, Andrew, Lawrence, Jeanne B.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696186/
https://ncbi.nlm.nih.gov/pubmed/19217333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.01.026
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