An Architectural Role for a Nuclear Non-coding RNA: NEAT1 RNA is Essential for the Structure of Paraspeckles

NEAT1 RNA, a highly abundant 4 kb ncRNA, is retained in nuclei in ~10–20 large foci that we show is completely coincident with paraspeckles, nuclear domains implicated in mRNA nuclear retention. Depletion of NEAT1 RNA via RNAi eradicates paraspeckles, suggesting it controls sequestration of the para...

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Autori principali: Clemson, Christine M., Hutchinson, John N., Sara, Sergio A., Ensminger, Alexander W., Fox, Archa H., Chess, Andrew, Lawrence, Jeanne B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696186/
https://ncbi.nlm.nih.gov/pubmed/19217333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.01.026
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