Identification of residues in the Cμ4 domain of polymeric IgM essential for interaction with P. falciparum erythrocyte membrane protein 1 (PfEMP1)

The binding of non-specific human IgM to the surface of infected erythrocytes is important in rosetting, a major virulence factor in the pathogenesis of severe malaria due to Plasmodium falciparum, and IgM binding has also been implicated in placental malaria. Here we have identified the IgM-binding...

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Huvudupphovsmän: Ghumra, Ashfaq, Semblat, Jean-Philippe, McIntosh, Richard S., Raza, Ahmed, Rasmussen, Ingunn B., Braathen, Ranveig, Johansen, Finn-Eirik, Sandlie, Inger, Mongini, Patricia K., Rowe, J. Alexandra, Pleass, Richard J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696179/
https://ncbi.nlm.nih.gov/pubmed/18641336
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