Immunisation with Recombinant PfEMP1 Domains Elicits Functional Rosette-Inhibiting and Phagocytosis-Inducing Antibodies to Plasmodium falciparum

BACKGROUND: Rosetting is a Plasmodium falciparum virulence factor implicated in the pathogenesis of life-threatening malaria. Rosetting occurs when parasite–derived P. falciparum Erythrocyte Membrane Protein One (PfEMP1) on the surface of infected erythrocytes binds to human receptors on uninfected...

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Detalhes bibliográficos
Main Authors: Ghumra, Ashfaq, Khunrae, Pongsak, Ataide, Ricardo, Raza, Ahmed, Rogerson, Stephen J., Higgins, Matthew K., Rowe, J. Alexandra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031562/
https://ncbi.nlm.nih.gov/pubmed/21305024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016414
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