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The transcription factors Stat5a/b are not required for islet development but modulate pancreatic β-cell physiology upon aging

In insulinoma cell lines proliferation and insulin gene transcription are stimulated by growth hormone and prolactin, which convey their signals through the transcription factors Stat5a and 5b (referred to as Stat5). However, the contribution of Stat5 to the physiology of β-cells in vivo could not b...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lee, Ji-Yeon, Gavrilova, Oksana, Davani, Behrous, Robinson, Gertraud W., Hennighausen, Lothar
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695665/
https://ncbi.nlm.nih.gov/pubmed/17599554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2007.05.010
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