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The transcription factors Stat5a/b are not required for islet development but modulate pancreatic β-cell physiology upon aging

In insulinoma cell lines proliferation and insulin gene transcription are stimulated by growth hormone and prolactin, which convey their signals through the transcription factors Stat5a and 5b (referred to as Stat5). However, the contribution of Stat5 to the physiology of β-cells in vivo could not b...

詳細記述

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書誌詳細
主要な著者: Lee, Ji-Yeon, Gavrilova, Oksana, Davani, Behrous, Robinson, Gertraud W., Hennighausen, Lothar
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695665/
https://ncbi.nlm.nih.gov/pubmed/17599554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2007.05.010
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