In vivo Enhancement of Peptide Display by MHC class II Molecules with Small Molecule Catalysts of Peptide Exchange

Rapid binding of peptides to MHC class II molecules is normally limited to a deep endosomal compartment where the coordinate action of low pH and HLA-DM displaces the invariant chain remnant CLIP or other peptides from the binding site. Exogenously added peptides are subject to proteolytic degradati...

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Main Authors: Call, Melissa J., Xing, Xuechao, Cuny, Gregory D., Seth, Nilufer P., Altmann, Daniel M., Fugger, Lars, Krogsgaard, Michelle, Stein, Ross L., Wucherpfennig, Kai W.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695398/
https://ncbi.nlm.nih.gov/pubmed/19414787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803464
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