Functional Characterization of Premnaspirodiene Oxygenase, a Cytochrome P450 Catalyzing Regio- and Stereo-specific Hydroxylations of Diverse Sesquiterpene Substrates

Solavetivone, a potent antifungal phytoalexin, is derived from a vetispirane-type sesquiterpene, premnaspirodiene, by a putative regio- and stereo-specific hydroxylation, followed by a second oxidation to yield the α,β-unsaturated ketone. Mechanistically, these reactions could occur via a single, mu...

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Main Authors: Takahashi, Shunji, Yeo, Yun-Soo, Zhao, Yuxin, O’Maille, Paul E., Greenhagen, Bryan T., Noel, Joseph P., Coates, Robert M., Chappell, Joe
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695360/
https://ncbi.nlm.nih.gov/pubmed/17715131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M703378200
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