Kinetic and Molecular Analysis of 5-Epiaristolochene 1,3-Dihydroxylase, a Cytochrome P450 Enzyme Catalyzing Successive Hydroxylations of Sesquiterpenes

The final step of capsidiol biosynthesis is catalyzed by 5-epiaristolochene dihydroxylase (EAH), a cytochrome P450 enzyme that catalyzes the regio- and stereospecific insertion of two hydroxyl moieties into the bicyclic sesquiterpene 5-epiaristolochene (EA). Detailed kinetic studies using EA and the...

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Main Authors: Takahashi, Shunji, Zhao, Yuxin, O’Maille, Paul E., Greenhagen, Bryan T., Noel, Joseph P., Coates, Robert M., Chappell, Joe
格式: Artigo
語言:Inglês
出版: 2004
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859954/
https://ncbi.nlm.nih.gov/pubmed/15522862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M411870200
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