α-Helix targeting reduces amyloid-β peptide toxicity

The amyloid-β peptide (Aβ) can generate cytotoxic oligomers, and their accumulation is thought to underlie the neuropathologic changes found in Alzheimer's disease. Known inhibitors of Aβ polymerization bind to undefined structures and can work as nonspecific aggregators, and inhibitors that ta...

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Bibliographische Detailangaben
Hauptverfasser: Nerelius, C., Sandegren, A., Sargsyan, H., Raunak, R., Leijonmarck, H., Chatterjee, U., Fisahn, A., Imarisio, S., Lomas, D. A., Crowther, D. C., Strömberg, R., Johansson, J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695042/
https://ncbi.nlm.nih.gov/pubmed/19458258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810364106
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