α-Helix targeting reduces amyloid-β peptide toxicity

The amyloid-β peptide (Aβ) can generate cytotoxic oligomers, and their accumulation is thought to underlie the neuropathologic changes found in Alzheimer's disease. Known inhibitors of Aβ polymerization bind to undefined structures and can work as nonspecific aggregators, and inhibitors that ta...

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Главные авторы: Nerelius, C., Sandegren, A., Sargsyan, H., Raunak, R., Leijonmarck, H., Chatterjee, U., Fisahn, A., Imarisio, S., Lomas, D. A., Crowther, D. C., Strömberg, R., Johansson, J.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2009
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695042/
https://ncbi.nlm.nih.gov/pubmed/19458258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810364106
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