α-Helix targeting reduces amyloid-β peptide toxicity

The amyloid-β peptide (Aβ) can generate cytotoxic oligomers, and their accumulation is thought to underlie the neuropathologic changes found in Alzheimer's disease. Known inhibitors of Aβ polymerization bind to undefined structures and can work as nonspecific aggregators, and inhibitors that ta...

詳細記述

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書誌詳細
主要な著者: Nerelius, C., Sandegren, A., Sargsyan, H., Raunak, R., Leijonmarck, H., Chatterjee, U., Fisahn, A., Imarisio, S., Lomas, D. A., Crowther, D. C., Strömberg, R., Johansson, J.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2009
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695042/
https://ncbi.nlm.nih.gov/pubmed/19458258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810364106
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