20-Hydroxycholecalciferol, Product of Vitamin D3 Hydroxylation by P450scc, Decreases NF-κB Activity by Increasing IκBα Levels in Human Keratinocytes

The side chain of vitamin D3 is hydroxylated in a sequential manner by cytochrome P450scc (CYP11A1) to form 20-hydroxycholecalciferol, which can induce growth arrest and differentiation of both primary and immortalized epidermal keratinocytes. Since nuclear factor-κB (NF-κB) plays a pivotal role in...

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Bibliografiske detaljer
Main Authors: Janjetovic, Zorica, Zmijewski, Michal A., Tuckey, Robert C., DeLeon, Damon A., Nguyen, Minh N., Pfeffer, Lawrence M., Slominski, Andrzej T.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694402/
https://ncbi.nlm.nih.gov/pubmed/19543524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005988
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