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Gain-of-Function Mutational Activation of Human tRNA Synthetase Procytokine
Disease-causing mutations occur in genes for aminoacyl tRNA synthetases. That some mutations are dominant suggests a gain-of-function. Native tRNA synthetases, like TyrRS and TrpRS, catalyze aminoacylation and are also procytokines that are activated by natural fragmentation. In principle, however,...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2693404/ https://ncbi.nlm.nih.gov/pubmed/18096501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.10.016 |
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