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Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase
Higher eukaryote tRNA synthetases have expanded functions with roles in the assembly of biological systems. New functions come from enlarged, more differentiated structures that were adapted to fit with the essential aminoacylation function. How those adaptations affect catalytic mechanism is not kn...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2104486/ https://ncbi.nlm.nih.gov/pubmed/17637340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.05.009 |
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