Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase

Higher eukaryote tRNA synthetases have expanded functions with roles in the assembly of biological systems. New functions come from enlarged, more differentiated structures that were adapted to fit with the essential aminoacylation function. How those adaptations affect catalytic mechanism is not kn...

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Bibliographische Detailangaben
Hauptverfasser: Yang, Xiang-Lei, Guo, Min, Kapoor, Mili, Ewalt, Karla L., Otero, Francella J., Skene, Robert J., McRee, Duncan E., Schimmel, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2104486/
https://ncbi.nlm.nih.gov/pubmed/17637340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.05.009
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