Gain-of-Function Mutational Activation of Human tRNA Synthetase Procytokine

Disease-causing mutations occur in genes for aminoacyl tRNA synthetases. That some mutations are dominant suggests a gain-of-function. Native tRNA synthetases, like TyrRS and TrpRS, catalyze aminoacylation and are also procytokines that are activated by natural fragmentation. In principle, however,...

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Main Authors:	Yang, Xiang-Lei, Kapoor, Mili, Otero, Francella J., Slike, Bonnie M., Tsuruta, Hiro, Frausto, Ricardo, Bates, Alison, Ewalt, Karla L., Cheresh, David A., Schimmel, Paul
Format:	Artigo
Language:	Inglês
Published:	2007
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2693404/ https://ncbi.nlm.nih.gov/pubmed/18096501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.10.016
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Gain-of-Function Mutational Activation of Human tRNA Synthetase Procytokine

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