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Ubiquitin-family modifications of topoisomerase I in camptothecin-treated human breast cancer cells
Camptothecins kill mammalian cells by stabilizing topoisomerase I-DNA strand passing intermediates that are converted to lethal double strand DNA breaks in DNA replication fork collisions. Camptothecin-stabilized topoisomerase I-DNA cleavage intermediates in mammalian cells are uniquely modified by...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2693397/ https://ncbi.nlm.nih.gov/pubmed/19236054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802179t |
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