Ubiquitin-family modifications of topoisomerase I in camptothecin-treated human breast cancer cells

Camptothecins kill mammalian cells by stabilizing topoisomerase I-DNA strand passing intermediates that are converted to lethal double strand DNA breaks in DNA replication fork collisions. Camptothecin-stabilized topoisomerase I-DNA cleavage intermediates in mammalian cells are uniquely modified by...

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Hlavní autoři: Kanagasabai, Ragu, Liu, Shujun, Salama, Samir, Yamasaki, Edith F., Zhang, Liwen, Greenchurch, Kari B., Snapka, Robert M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693397/
https://ncbi.nlm.nih.gov/pubmed/19236054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802179t
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