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Structural and functional consequences of the substitution of glycine 65 by arginine in the N-lobe of human transferrin
The G65R mutation in the N-lobe of human transferrin was created to mimic a naturally occurring variant (G394R) found in the homologous C-lobe. Because Gly65 is hydrogen-bonded to the iron-binding ligand Asp63, it comprises part of the second shell hydrogen bond network surrounding the iron within t...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2693239/ https://ncbi.nlm.nih.gov/pubmed/19219998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802254x |
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