Structural and functional consequences of the substitution of glycine 65 by arginine in the N-lobe of human transferrin

The G65R mutation in the N-lobe of human transferrin was created to mimic a naturally occurring variant (G394R) found in the homologous C-lobe. Because Gly65 is hydrogen-bonded to the iron-binding ligand Asp63, it comprises part of the second shell hydrogen bond network surrounding the iron within t...

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Main Authors: Mason, Anne B., Halbrooks, Peter J., James, Nicholas G., Byrne, Shaina L., Grady, John K., Chasteen, N. Dennis, Bobst, Cedric E., Kaltashov, Igor A., Smith, Valerie C., MacGillivray, Ross T. A., Everse, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693239/
https://ncbi.nlm.nih.gov/pubmed/19219998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802254x
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