Alzheimer’s presenilin 1 causes chromosome missegregation and aneuploidy

Mutations in the presenilin 1 gene cause most early-onset familial Alzheimer’s disease (FAD). Here we report that a defect in the cell cycle—improper chromosome segregation—can be caused by abnormal presenilin function and therefore may contribute to AD pathogenesis. Specifically we find that either...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Boeras, Debrah I., Granic, Antoneta, Padmanabhan, Jaya, Crespo, Nichole C., Rojiani, Amyn M., Potter, Huntington
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2006
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692942/
https://ncbi.nlm.nih.gov/pubmed/17169464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2006.10.027
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items