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Alzheimer’s presenilin 1 causes chromosome missegregation and aneuploidy
Mutations in the presenilin 1 gene cause most early-onset familial Alzheimer’s disease (FAD). Here we report that a defect in the cell cycle—improper chromosome segregation—can be caused by abnormal presenilin function and therefore may contribute to AD pathogenesis. Specifically we find that either...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692942/ https://ncbi.nlm.nih.gov/pubmed/17169464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2006.10.027 |
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