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Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors
Chromosome mis-segregation and aneuploidy are greatly induced in Alzheimer disease and models thereof by mutant forms of the APP and PS proteins and by their product, the Aβ peptide. Here we employ human somatic cells and Xenopus egg extracts to show that Aβ impairs the assembly and maintenance of t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3356829/ https://ncbi.nlm.nih.gov/pubmed/21566458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.9.15478 |
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