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Alzheimer Aβ inhibition of eg5/kin5 reduces neurotrophin/transmitter receptor function

The mechanism by which Aβ causes neuronal dysfunction/death in Alzheimer’s disease is unclear. Previously, we showed that Aβ inhibits several microtubule-dependent kinesin motors essential for mitosis and also present in mature neurons. Here we show that inhibition of kinesin 5 (Eg5) by Aβ blocks ne...

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Detalhes bibliográficos
Main Authors: Ari, Csilla, Borysov, Sergiy I., Wu, Jiashin, Padmanabhan, Jaya, Potter, Huntington
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084549/
https://ncbi.nlm.nih.gov/pubmed/24636920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.02.006
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