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The IFN-γ-induced Transcriptional Program of the CIITA Gene is Inhibited by Statins
Statins are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors that exert anti-inflammatory effects. IFN-γ induction of class II MHC expression, which requires the class II transactivator (CIITA), is inhibited by statins, however, the molecular basis for suppression is undetermined...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692880/ https://ncbi.nlm.nih.gov/pubmed/18601229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838189 |
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