Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function

Germline mutations in two major susceptibility genes, BRCA1 and BRCA2, account for nearly 20% of familial breast cancers. A majority of the remaining genetic factors involved in heritable breast cancer susceptibility are, however, unknown. Recently, a new BRCA1-interacting protein, RAP80, was identi...

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Detalhes bibliográficos
Main Authors: Nikkilä, Jenni, Coleman, Kara A., Morrissey, Devon, Pylkäs, Katri, Erkko, Hannele, Messick, Troy E., Karppinen, Sanna-Maria, Amelina, Aljona, Winqvist, Robert, Greenberg, Roger A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692655/
https://ncbi.nlm.nih.gov/pubmed/19305427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.33
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