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Upregulation of RGS4 expression by IL-1β in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3β pathway
Initial Ca(2+)-dependent contraction of intestinal smooth muscle is inhibited upon IL-1β treatment. The decrease in contraction reflects the upregulation of regulator of G protein signaling-4 (RGS4) via the canonical inhibitor of NF-κB kinase-2 (IKK2)/IκB-α/NF-κB pathway. Here, we show that the acti...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692422/ https://ncbi.nlm.nih.gov/pubmed/19369446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00573.2008 |
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