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New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential

The molecular chaperone Hsp90 (heat shock protein 90) is a promising target in cancer therapy. Preclinical and clinical evaluations of a variety of Hsp90 inhibitors have shown antitumor effect as a single agent and in combination with chemotherapy. Current Hsp90 inhibitors are categorized into sever...

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Detalhes bibliográficos
Main Authors: Li, Yanyan, Zhang, Tao, Sun, Duxin
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692088/
https://ncbi.nlm.nih.gov/pubmed/19179103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drup.2008.12.002
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