The structure of the human tRNA(Lys3) anticodon bound to the HIV genome is stabilized by modified nucleosides and adjacent mismatch base pairs

Replication of human immunodeficiency virus (HIV) requires base pairing of the reverse transcriptase primer, human tRNA(Lys3), to the viral RNA. Although the major complementary base pairing occurs between the HIV primer binding sequence (PBS) and the tRNA's 3′-terminus, an important discrimina...

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Bibliographic Details
Main Authors: Bilbille, Yann, Vendeix, Franck A. P., Guenther, Richard, Malkiewicz, Andrzej, Ariza, Xavier, Vilarrasa, Jaume, Agris, Paul F.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691828/
https://ncbi.nlm.nih.gov/pubmed/19324888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp187
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