The structure of the human tRNA(Lys3) anticodon bound to the HIV genome is stabilized by modified nucleosides and adjacent mismatch base pairs

Replication of human immunodeficiency virus (HIV) requires base pairing of the reverse transcriptase primer, human tRNA(Lys3), to the viral RNA. Although the major complementary base pairing occurs between the HIV primer binding sequence (PBS) and the tRNA's 3′-terminus, an important discrimina...

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Detalhes bibliográficos
Main Authors: Bilbille, Yann, Vendeix, Franck A. P., Guenther, Richard, Malkiewicz, Andrzej, Ariza, Xavier, Vilarrasa, Jaume, Agris, Paul F.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691828/
https://ncbi.nlm.nih.gov/pubmed/19324888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp187
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