The structure of the human tRNA(Lys3) anticodon bound to the HIV genome is stabilized by modified nucleosides and adjacent mismatch base pairs

Replication of human immunodeficiency virus (HIV) requires base pairing of the reverse transcriptase primer, human tRNA(Lys3), to the viral RNA. Although the major complementary base pairing occurs between the HIV primer binding sequence (PBS) and the tRNA's 3′-terminus, an important discrimina...

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Autores principales: Bilbille, Yann, Vendeix, Franck A. P., Guenther, Richard, Malkiewicz, Andrzej, Ariza, Xavier, Vilarrasa, Jaume, Agris, Paul F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2009
Materias:
Structural Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691828/
https://ncbi.nlm.nih.gov/pubmed/19324888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp187
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