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Structural insights into the cooperative binding of SeqA to a tandem GATC repeat

SeqA is a negative regulator of DNA replication in Escherichia coli and related bacteria that functions by sequestering the origin of replication and facilitating its resetting after every initiation event. Inactivation of the seqA gene leads to unsynchronized rounds of replication, abnormal localiz...

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Bibliographic Details
Main Authors: Chung, Yu Seon, Brendler, Therese, Austin, Stuart, Guarné, Alba
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691817/
https://ncbi.nlm.nih.gov/pubmed/19304745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp151
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