S1P(1) receptor signaling overrides retention mediated by Gα(i)-coupled receptors to promote T cell egress

The mechanism by which sphingosine-1-phosphate receptor-1 (S1P(1)) acts to promote lymphocyte egress from lymphoid organs is not defined. Here we showed that CCR7-deficient T cells left lymph nodes more rapidly than wild-type cells whereas CCR7 overexpressing cells were retained for longer. After tr...

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Detaylı Bibliyografya
Asıl Yazarlar: Pham, Trung H. M., Okada, Takaharu, Matloubian, Mehrdad, Lo, Charles G., Cyster, Jason G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691390/
https://ncbi.nlm.nih.gov/pubmed/18164221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.11.017
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