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S1P(1) receptor signaling overrides retention mediated by Gα(i)-coupled receptors to promote T cell egress
The mechanism by which sphingosine-1-phosphate receptor-1 (S1P(1)) acts to promote lymphocyte egress from lymphoid organs is not defined. Here we showed that CCR7-deficient T cells left lymph nodes more rapidly than wild-type cells whereas CCR7 overexpressing cells were retained for longer. After tr...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2691390/ https://ncbi.nlm.nih.gov/pubmed/18164221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.11.017 |
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