Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

Loss of NF-E2-related factor 2 (Nrf2) signaling increases susceptibility to acute toxicity, inflammation and carcinogenesis in mice due to the inability to mount adaptive responses. In contrast, disruption of Keap1 (a cytoplasmic modifier of Nrf2 turnover) protects against these stresses in mice, al...

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Autori principali: Yates, Melinda S., Tran, Quynh T., Dolan, Patrick M., Osburn, William O., Shin, Soona, McCulloch, Colin C., Silkworth, Jay B., Taguchi, Keiko, Yamamoto, Masayuki, Williams, Charlotte R., Liby, Karen T., Sporn, Michael B., Sutter, Thomas R., Kensler, Thomas W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2009
Soggetti:
Cancer Prevention
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691141/
https://ncbi.nlm.nih.gov/pubmed/19386581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp100
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