Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

Loss of NF-E2-related factor 2 (Nrf2) signaling increases susceptibility to acute toxicity, inflammation and carcinogenesis in mice due to the inability to mount adaptive responses. In contrast, disruption of Keap1 (a cytoplasmic modifier of Nrf2 turnover) protects against these stresses in mice, al...

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Bibliografiske detaljer
Main Authors: Yates, Melinda S., Tran, Quynh T., Dolan, Patrick M., Osburn, William O., Shin, Soona, McCulloch, Colin C., Silkworth, Jay B., Taguchi, Keiko, Yamamoto, Masayuki, Williams, Charlotte R., Liby, Karen T., Sporn, Michael B., Sutter, Thomas R., Kensler, Thomas W.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Cancer Prevention
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691141/
https://ncbi.nlm.nih.gov/pubmed/19386581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp100
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