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Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination
In late mitosis and G1, Mcm2-7 are assembled onto replication origins to “license” them for initiation. At other times licensing is inhibited by cyclin dependent kinases (CDKs) and geminin, thus ensuring that origins fire only once per cell cycle. We show here that, paradoxically, CDKs are also requ...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2004
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2691133/ https://ncbi.nlm.nih.gov/pubmed/14767479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1100 |
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