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Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination

In late mitosis and G1, Mcm2-7 are assembled onto replication origins to “license” them for initiation. At other times licensing is inhibited by cyclin dependent kinases (CDKs) and geminin, thus ensuring that origins fire only once per cell cycle. We show here that, paradoxically, CDKs are also requ...

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Detalhes bibliográficos
Main Authors: Li, Anatoliy, Blow, J. Julian
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691133/
https://ncbi.nlm.nih.gov/pubmed/14767479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1100
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