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Inhibition of Src with AZD0530 Reveals the Src-Focal Adhesion Kinase Complex as a Novel Therapeutic Target in Papillary and Anaplastic Thyroid Cancer

Context: Focal adhesion kinase (FAK) and Src are overexpressed and activated in many cancers and have been associated with tumor progression. The role of the Src-FAK complex has not been characterized in papillary and anaplastic thyroid cancer (PTC and ATC). Objective: The goal of this study was to...

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Главные авторы: Schweppe, Rebecca E., Kerege, Anna A., French, Jena D., Sharma, Vibha, Grzywa, Rachel L., Haugen, Bryan R.
Формат: Artigo
Язык:Inglês
Опубликовано: The Endocrine Society 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2690419/
https://ncbi.nlm.nih.gov/pubmed/19293266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2008-2511
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