Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine

Although oxidative stress has been implicated in acute acetaminophen-induced liver failure and in chronic liver cirrhosis and hepatocellular carcinoma (HCC), no common underlying metabolic pathway has been identified. Recent case reports suggest a link between the pentose phosphate pathway (PPP) enz...

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Detalhes bibliográficos
Main Authors: Hanczko, Robert, Fernandez, David R., Doherty, Edward, Qian, Yueming, Vas, Gyorgy, Niland, Brian, Telarico, Tiffany, Garba, Adinoyi, Banerjee, Sanjay, Middleton, Frank A., Barrett, Donna, Barcza, Maureen, Banki, Katalin, Landas, Steve K., Perl, Andras
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689120/
https://ncbi.nlm.nih.gov/pubmed/19436114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35722
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