Cleavage of Transaldolase by Granzyme B Causes the Loss of Enzymatic Activity with Retention of Antigenicity for Multiple Sclerosis Patients

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the CNS resulting from a progressive loss of oligodendrocytes. Transaldolase (TAL) is expressed at selectively high levels in oligodendrocytes of the brain, and postmortem sections show concurrent loss of myelin basic protein and TAL...

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Библиографические подробности
Главные авторы: Niland, Brian, Miklossy, Gabriella, Banki, Katalin, Biddison, William E., Casciola-Rosen, Livia, Rosen, Antony, Martinvalet, Denis, Lieberman, Judy, Perl, Andras
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117466/
https://ncbi.nlm.nih.gov/pubmed/20194725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804174
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