Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors

Adeno-associated virus (AAV) vectors are effective gene delivery vehicles mediating long-lasting transgene expression. Data from a clinical trial of AAV2-mediated hepatic transfer of the Factor IX gene (F9) into hemophilia B subjects suggests that CTL responses against AAV capsid can eliminate trans...

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Bibliographische Detailangaben
Hauptverfasser: Pien, Gary C., Basner-Tschakarjan, Etiena, Hui, Daniel J., Mentlik, Ashley N., Finn, Jonathan D., Hasbrouck, Nicole C., Zhou, Shangzhen, Murphy, Samuel L., Maus, Marcela V., Mingozzi, Federico, Orange, Jordan S., High, Katherine A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689109/
https://ncbi.nlm.nih.gov/pubmed/19436115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36891
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