Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells

The molecular mechanism of autocrine regulation of vascular endothelial growth factor (VEGF) in chronic lymphocytic leukemia (CLL) B cells is unknown. Here, we report that CLL B cells express constitutive levels of HIF-1α under normoxia. We have examined the status of the von Hippel-Lindau gene prod...

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Detalhes bibliográficos
Main Authors: Ghosh, Asish K., Shanafelt, Tait D., Cimmino, Amelia, Taccioli, Cristian, Volinia, Stefano, Liu, Chang-gong, Calin, George A., Croce, Carlo M., Chan, Denise A., Giaccia, Amato J., Secreto, Charla, Wellik, Linda E., Lee, Yean K., Mukhopadhyay, Debabrata, Kay, Neil E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689054/
https://ncbi.nlm.nih.gov/pubmed/19336759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-10-185686
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