Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector–transduced CD34(+) cells

We previously reported that lentiviral vectors derived from the simian immunodeficiency virus (SIV) were efficient at transducing rhesus hematopoietic repopulating cells. To evaluate the persistence of vector-containing and -expressing cells long term, and the safety implications of SIV lentiviral v...

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Detalhes bibliográficos
Main Authors: Kim, Yoo-Jin, Kim, Yoon-Sang, Larochelle, Andre, Renaud, Gabriel, Wolfsberg, Tyra G., Adler, Rima, Donahue, Robert E., Hematti, Peiman, Hong, Bum-Kee, Roayaei, Jean, Akagi, Keiko, Riberdy, Janice M., Nienhuis, Arthur W., Dunbar, Cynthia E., Persons, Derek A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689045/
https://ncbi.nlm.nih.gov/pubmed/19339698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-10-185199
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