Ex Vivo Expansion of Retrovirally Transduced Primate CD34(+) Cells Results in Overrepresentation of Clones With MDS1/EVI1 Insertion Sites in the Myeloid Lineage After Transplantation

Activation of proto-oncogenes by retroviral insertion is an important issue delaying clinical development of gene therapy. We have reported the nonrandom persistence of hematopoietic clones with vector insertions within the MDS1/EVI1 locus following transplantation of rhesus macaques. We now ask whe...

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Main Authors: Sellers, Stephanie, Gomes, Theotonius J, Larochelle, Andre, Lopez, Rebecca, Adler, Rima, Krouse, Allen, Donahue, Robert E, Childs, Richard W, Dunbar, Cynthia E
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956935/
https://ncbi.nlm.nih.gov/pubmed/20571542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.117
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