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Structure of the complex of a mitotic kinesin with its calcium binding regulator
Much of the transport, tension, and movement in mitosis depends on kinesins, the ATP-powered microtubule-based motors. We report the crystal structure of a kinesin complex, the mitotic kinesin KCBP bound to its principal regulator KIC. Shown to be a Ca(2+) sensor, KIC works as an allosteric trap. Ex...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2688874/ https://ncbi.nlm.nih.gov/pubmed/19416847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811131106 |
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