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Novel Binding of the Mitotic Regulator TPX2 (Target Protein for Xenopus Kinesin-like Protein 2) to Importin-α

Several aspects of mitotic spindle assembly are orchestrated by the Ran GTPase through its modulation of the interaction between spindle assembly factors and importin-α. One such factor is TPX2 that promotes microtubule assembly in the vicinity of chromosomes. TPX2 is inhibited when bound to importi...

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Detalhes bibliográficos
Main Authors: Giesecke, Astrid, Stewart, Murray
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878527/
https://ncbi.nlm.nih.gov/pubmed/20335181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102343
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